Fulham's on-loan Spurs midfielder Lewis Holtby will not be eligible to face his parent club when the two sides meet on in the early kick-off on Saturday.
The 23-year-old German, who has three full international caps, joined Fulham on loan from Spurs on the final day of the January transfer window.
Holtby scored his only Premier League goal for Spurs to date against Fulham in the reverse fixture at the beginning of December.
Whites boss Felix Magath was Holtby's manager when the pair were at Schalke and has handed the creative midfielder a key role in his side as they battle the drop to the Championship.
The Cottagers looked destined for Championship football when Magath succeeded Rene Meulensteen on February 14, but three wins and a draw from his first eight games has given Magath something to work with.
Having secured vital back-to-back victories over Norwich City and Aston Villa, Fulham trail the Canaries in 17th by just two points at this late stage.
Norwich, under the guidance of interim boss Neil Adams, have a horrific run-in as they take on Liverpool, Manchester United, Chelsea and Arsenal.
Fulham on the other hand, face Tottenham, Hull City, Stoke City and Crystal Palace in an eminently more winnable set of games.
From a Spurs' perspective, the game provides them with another chance to make some headway in the battle for fourth after drawing 3-3 at West Bromwich Albion last weekend.
Tim Sherwood's side lie in sixth, seven points behind fourth-place Arsenal and six points behind Everton in fifth after their midweek slip-up against Crystal Palace.
Spurs will welcome back former Fulham midfielder Mousa Dembele after the Belgian came through an Under-21 fixture against Manchester United on Monday evening.
Roberto Soldado and Michael Dawson have both returned to training following hamstring injuries.
Jan Vertonghen (ankle), Kyle Walker (pelvis), Etienne Capoue (ankle) and Erik Lamela (back) are all out though.
Young forward Cauley Woodrow is expected to be fit following a thigh problem, whilst Kostas Mitroglu and Damien Duff are both sidelined with knee problems.